CORDIS Project
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This project investigates how cancer cells manage acidity, focusing on the role of pH in tumor behavior and evolution. By analyzing proton dynamics and their effects on gene expression, it aims to understand cancer progression and identify potential therapeutic targets.
Metabolism generates vast quantities of acid, which exerts broad-spectrum biological effects because protein protonation is a powerful post-translational modification.
Regulation of intracellular pH (pHi) is therefore a homeostatic priority, but carefully orchestrated proton dynamics are a versatile signal.Extracellular acidity is an established chemical signature of tumours and has recently been proposed to convey a signal that shapes the phenotypic landscape of cancer.
Cancers genetic instabil…
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