CORDIS Project
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This project aims to identify mechanisms that protect against epilepsy by studying a newly discovered process called supply-rate depression. It involves genetically engineered mice to explore how synaptic changes can lead to new anti-epileptic drugs with fewer side effects.
Epilepsy is a prevalent neurological disorder affecting more than 1 % of all people, with the estimated number of 900,000 children and adolescents suffering from active epilepsy in Europe.
Most current drugs targeting this disease have important adverse side-effects.
An ideal drug would, however, potentiate the endogenous anti-seizure mechanisms that keep most humans epilepsy-free.To date, these native “anti-seizure mechanisms” have not been identified.
Recently, a novel candidate mechanism term…
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