CORDIS Project
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This project investigates the role of small ubiquitin-like modifiers (SUMO) in protein modification, focusing on the structure and function of SUMO E3 ligases and their downstream effects. It aims to develop new methods for identifying SUMO-related protein complexes, contributing to our understanding of cellular proces…
Protein post-translational modification with small ubiquitin-like modifiers (SUMO1, -2, and -3), also known as SUMOylation, targets a third of human proteins, is essential for organisms from yeast to humans, and has strong links to cancer and neurodegeneration.
Like ubiquitylation, to which it is related, SUMOylation typically depends on the action of enzymes called E3 ligases, which help determine substrate specificity and the exact signal that is produced.
However, while for ubiquitylation sev…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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