CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This research aims to elucidate the role of Small Ubiquitin-like Modifier in synaptic plasticity, particularly how it regulates kainate receptors in response to neuronal activity. The study combines electrophysiological and biochemical techniques to explore these mechanisms.
The aim of this work is to demonstrate the role of SUMO (Small Ubiquitin like MOdifier) in synaptic plasticity.
Specifically, my goal is to show that synaptic kainate receptors (KARs) are regulated in an activity-dependent manner that involves their SUMOylation.
Recently, Mellor and Henley have discovered that the KAR subunit GluR6 is a substrate for SUMO and that SUMOylation of GluR6 causes KARs to be endocytosed.
This was demonstrated for synaptic KARs at mossy fibre synapses in the hippocampu…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
