CORDIS Project
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This project investigates the role of SUMOylation, a type of protein modification, in cellular regulation. It aims to understand how SUMOylation targets groups of proteins and its implications for cellular functions and medical applications.
Posttranslational modification (PTM) of proteins by ubiquitin family proteins is of fundamental importance for cellular function, regulation and development.
Ubiquitylation typically targets individual proteins, and high selectivity is achieved by a plethora of ubiquitin-conjugating enzymes and ligases.
Much less is known regarding how modification by the ubiquitin-related protein SUMO influences the function of substrates and how specificity is provided.
Surprisingly, although SUMOylation affec…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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