CORDIS Project
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This project explores the role of sumoylation in the function of Protocadherin-10, a protein linked to autism. It aims to understand how sumoylation affects synapse elimination and its implications for neurodevelopmental disorders, particularly in individuals with Pcdh10 mutations.
Sumoylation is an essential post-translational modification that regulates a wide range of cellular functions.
Interestingly, several proteins involved in synaptic functions have been shown to be SUMO targets.
Unpublished data from my current lab identified a list of SUMO substrates at the synapse.
Among them, we find Protocadherin-10 (PCDH10), an autism-related cell adhesion transmembrane protein.
Mice lacking one copy of Pcdh10 gene present abnormal spine density and morphology, reduced expres…
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