CORDIS Project
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The SUMMA project aims to advance cardiac regeneration by stimulating the proliferation of heart muscle cells using gene therapy. It focuses on utilizing microRNAs to enhance the body's natural healing process after ischemic heart damage, with plans for proof-of-concept studies in large animal models.
Most people who develop ischemic HF have (or had) an ischemic heart condition first (e.g. myocardial infarction, MI).
Restoring damaged heart muscle tissue therefore represents a fundamental mechanistic strategy to treat HF.
Cardiac regeneration after ischemic damage can be achieved by stimulating the proliferation of already existing (endogenous) cardiomyocytes rather than having to rely on the implantation of exogenous cells (i.e. stem cell therapy).
Compelling evidence supports that expanding…
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