CORDIS Project
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This project investigates the biological roles of rhomboid proteases by identifying their natural substrates in bacteria and mammals. Using advanced techniques, it aims to uncover the mechanisms of these enzymes, which could lead to new therapeutic inhibitors for diseases linked to rhomboid function.
Rhomboids are widely conserved intramembrane proteases.
They are known to control important biological processes in model insect, worm, yeast and protozoan species, but their functions in most organisms including mammals and bacteria are unknown.
The key to the understanding of rhomboid functions are their natural substrates, but it has been unclear how these are selected and recognized and methods for substrate identification have been lacking, which is limiting progress in the field.The core o…
USTAV ORGANICKE CHEMIE A BIOCHEMIE, AV CR, V.V.I.
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