CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project focuses on understanding the assembly of the spliceosome, a crucial enzyme in gene expression. By reconstituting and analyzing the structure of the survival of motor neuron complex and its interactions, the research aims to clarify the mechanisms behind small nuclear ribonucleoprotein biogenesis and its im…
The spliceosome is a multi-megadalton enzyme that catalyses the excision of non-coding introns from nuclear pre-mRNA.
It is assembled from five small nuclear ribonucleoprotein particles (snRNPs) and non-snRNP factors, while each snRNP contains a unique small nuclear RNA (snRNA, U1-U5) and is bound by the heptameric Sm-ring.
Acquisition of the Sm-ring is a key quality control step in snRNP biogenesis, defects of which are linked with several human diseases.
In humans, snRNP biogenesis requires at…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
Guests see up to 5 keywords.
