CORDIS Project
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This project investigates the SRP-independent targeting pathway for integral membrane proteins in yeast, focusing on the roles and interactions of SND components involved in their insertion into the endoplasmic reticulum. Using structural biology and biophysics, it aims to clarify the mechanisms of substrate capture an…
One-third of eukaryotic genes encode for integral membrane proteins (IMPs) with the majority being assembled at the endoplasmic reticulum (ER) after being translated by the ribosome.
The SRP-independent (SND) targeting pathway was recently identified as a new route for ER targeting and insertion of IMPs.
It was found to recognise a subset of IMPs with a central transmembrane domain, yet it also serves as an alternative route to deliver a broad range of substrates to the ER when their canonical p…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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