CORDIS Project
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This project aims to structurally analyze the γ-secretase complex, which is crucial in Alzheimer's disease. By using advanced imaging techniques, it seeks to uncover the molecular mechanisms of γ-secretase, providing insights for potential therapeutic interventions.
The γ-secretase intramembrane protease complex plays a critical role in multiple cellular processes including Notch signaling and secretion of amyloid β peptides, the accumulation of which causes Alzheimer’s disease (AD).
The enzymatic activity of γ-secretase is, therefore, a prime target for intervention in AD and is of major interest.
Yet, despite the detailed knowledge of γ-secretase's function in various cellular processes and disease, structural information regarding the complex is extremel…
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