CORDIS Project
Funding breakdown and partner intelligence are Premium
Sign in and upgrade to Premium for EU contribution totals, consortium analytics, OpenAlex research context, and AI summaries. · 0 consortium intelligence fields visible of 1
Start free • Cancel anytime • 14-day refund guarantee
This project investigates the structural changes in G protein-coupled receptors (GPCRs) upon ligand binding, focusing on cannabinoid receptor type 2 and beta-1 adrenergic receptor. It aims to engineer stable GPCR variants for biophysical studies, enhancing understanding of receptor activation mechanisms to inform drug…
G protein-coupled receptors (GPCRs) are eukaryotic seven-alpha-helix transmembrane proteins which are involved in extracellular signal transduction across the cellular membrane.
Aim of the proposed research is to structurally characterise ligand-induced conformational changes in GPCRs, to identify the number of alternative conformations the GPCR can adopt, and to engineer conformationally stabilised GPCR variants for subsequent biophysical and crystallographic studies.
The research will focus o…
PAUL SCHERRER INSTITUT
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Similar projects, consortium collaboration history, frequent partners, and OpenAlex research context.
Guests see up to 5 EuroSciVoc fields.
Guests see up to 5 topics.
