CORDIS Project
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The project focuses on the structural characterization of filamentous bacteriophages using advanced solid-state nuclear magnetic resonance techniques. By studying different phages, it aims to clarify their assembly processes and improve understanding of their interactions with host bacteria.
Filamentous bacteriophages comprise a family of viruses that share a similar virion structure and life cycle.
The virion is composed of a circular ssDNA wrapped by thousands of similar copies of a major coat protein and several different minor coat proteins in both ends.
Due to the mass (tens of MegaDaltons) and dimensions (~7 nm in diameter, 600 – 2000 nm in length) of filamentous phages, structural models have been obtained primarily from fiber diffraction, and from static solid state NMR of a…
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