CORDIS Project
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This project focuses on understanding the aggregation of alpha-synuclein protein, which is linked to Parkinson's disease. It aims to characterize early toxic forms of this protein using advanced techniques to identify potential therapeutic targets for treatment.
Alpha-synuclein (AS) is the major constituent of Lewy bodies, a pathological signature of Parkinson’s disease (PD).
Amyloid-like deposits of AS are generated by toxic pre-fibrillar species of the protein which are now considered to be a major cause of cell death in PD.
The mechanisms by which oxidative stress is linked to AS aggregation are not yet known and are a subject of intense research in the field.
The most appealing hypothesis is the one of oxidation-mediated oligomerization of AS, causi…
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