CORDIS Project
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This project aims to explore the assembly of the minor spliceosome, a critical component in gene expression, using cryo-electron microscopy. By analyzing the structure of specific complexes, it seeks to uncover the mechanisms behind spliceosome function and its role in various diseases.
Minor spliceosome is responsible for the removal of a rare class of introns that are present in many essential genes.
Despite its fundamental importance, much information remains elusive for a comprehensive understanding of minor spliceosome assembly and the molecular basis of the diseases associated with its malfunctions in human.
In this proposal, I will investigate the assembly process of U4atac/U6atac•U5 tri-snRNP (minor tri-snRNP) by isolating relevant complexes from human cells and determi…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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