CORDIS Project
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This project investigates the role of stress responses in the tumor microenvironment and their contribution to cancer progression. By analyzing tumor samples, the research aims to identify mechanisms that promote malignancy and potential therapeutic targets.
The contribution of genetic and epigenetic changes to rewiring of cancer cells into their malignant state has been much studied.
But tumors are more than cancer cells and the tumor microenvironment (TME) is a key player in tumor progression.
We lack an overarching view of how, despite being genomically stable, the TME is heterogeneously reprogrammed across time and space to promote evolution of aggressive disease.Recently I discovered that Heat-Shock Factor 1 (HSF1), a cytoprotective transcripti…
WEIZMANN INSTITUTE OF SCIENCE
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