CORDIS Project
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This project investigates how the structure of lymph nodes influences immune responses. By analyzing single cell data and imaging techniques, it aims to understand the role of stromal cells in immunity and how their organization affects responses to allergens and infections, particularly in asthma.
The immune system is faced with a substantial challenge – it must provide rapid, tailored immunity to the host without a priori knowledge of when, where and which pathogen will invade, and at the same avoid damage to self.
Recent evidence, including my own prior work, suggests that the anatomical organization of the lymphoid organ in which the immune response is initiated determines the quality and quantity of the response.
Lymph nodes (LNs) are supported by a scaffold of mesenchyme-derived stro…
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