CORDIS Project
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The project focuses on understanding the structural and functional dynamics of the brain-derived neurotrophic factor and its receptor, TrkB. It aims to elucidate the activation mechanisms that promote neuronal health and synaptic repair.
Neuronal circuit development involves multiple stages that are regulated by neurotrophic factors.
One of the key players, the brain-derived neurotrophic factor (BDNF), is involved in the development and functional modulation of circuits by promoting neuronal survival, synaptogenesis, synaptic transmission and synaptic plasticity. BDNF acts by binding to the tropomyosin-related kinase receptor B (TrkB), a type-I membrane protein, to trigger downstream signaling.
However, the molecular architectur…
UNITED KINGDOM RESEARCH AND INNOVATION
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United Kingdom, Oxford
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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