CORDIS Project
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This project investigates the mechanisms behind bacterial persistence, particularly focusing on the stringent response in bacteria. By understanding how environmental factors influence persister cell formation, it aims to develop new strategies for treating chronic bacterial infections.
Difficult-to-treat chronic and recurrent bacterial infections are often caused by bacteria that are sensitive to commonly used antibiotics.
The reasons for this recalcitrance are frequently unknown.
However, when grown in the laboratory, all bacteria, including major pathogens form persister cells that are multidrug tolerant, a phenomenon thought to be a major factor underlying recalcitrant infections.
We observed that the general bacterial stress response, known as “the stringent response”, pla…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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