CORDIS Project
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The project investigates the role of the RHBDL4 protease in cellular processes, particularly in quality control mechanisms. By developing methods to identify its substrates, the research aims to enhance understanding of RHBDL4's function and its implications in cancer biology.
Intramembrane proteolysis is increasingly understood to control many cellular processes but we still know little about the role of most intramembrane proteases.
The major roadblock is the lack of a robust method of protease substrate discovery.
In this action, I focus on RHBDL4, a poorly understood but highly conserved member of the rhomboid intramembrane serine protease family, which participates in ER associated degradation (ERAD), apoptosis and exocytosis, and which has been frequently implic…
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