CORDIS Project
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This project examines how chronic stress affects the prefrontal cortex and cognitive functions. By manipulating gene expression in mice, it aims to uncover the molecular mechanisms linking stress exposure to cognitive impairments, contributing to understanding mental disorders.
The prefrontal cortex (PFC) is a locus for higher-order cognition and executive control across species.
In most mental disorders such as depression or schizophrenia, dysfunction in PFC and its related neuronal networks has been associated with a variety of cognitive impairments.
Chronic stress exposure and abnormal levels of glucocorticoid stress hormone (GCs) is a key environmental risk factor for psychiatric illness.
The PFC is highly vulnerable to stress exposure and many studies have reporte…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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