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The StressOME project aims to understand the aggregation process of TDP-43, a protein linked to amyotrophic lateral sclerosis (ALS). By analyzing stress granules in patient-derived skin cells, the project seeks to identify genetic factors that influence TDP-43 dynamics and contribute to the disease.
How do you study a disease with no known cause?
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease.
Patients typically die 3-5 years after symptom onset.
There is no cure.
Finding a cure is hindered by the lack of obvious causes: although 10% of patients show familial inheritance (fALS), 90% of patients exhibit a sporadic form of ALS with no known cause (sporadic ALS, sALS).
Almost all ALS patients demonstrate intracellular inclusions of the RNA binding protein TDP-43…
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