CORDIS Project
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This project investigates how branched ubiquitin chains influence cellular responses to stress. By developing innovative tools and methods, the research aims to uncover the unique signals conveyed by these chains, enhancing our understanding of cellular regulation and homeostasis.
Posttranslational modification of proteins with monoubiquitin or different polyubiquitin chains alter protein function to signal distinct responses in cells and thereby regulate every aspect of eukaryotic biology.
Recently, ubiquitin has also been reported to form branched heterotypic chains.
The central premise of this proposal is that branched ubiquitin chains adopt unique conformations and convey distinct intracellular signals essential for maintaining cellular homeostasis.
We posit that bran…
UNIVERSITY OF DUNDEE
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