CORDIS Project
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This project investigates the relationship between stress hormones and the development of Alzheimer's disease. It aims to understand how stress influences the production of amyloid beta peptides, which are linked to cognitive decline, using advanced neurobiological techniques.
Global increases in lifespan make the challenge to prevent and treat Alzheimer’s disease (AD) urgent.
While the etiology of non-familial/sporadic AD is largely unknown, many AD patients have elevated stress hormone (glucocorticoid, GC) levels and recent animal studies show that high GC levels promote production of amyloidogenic peptides (key pathogenic players in AD) in association with memory deficits.
Stress/GC are implicated in mood and cognitive disorders, and meta-analyses identify depressi…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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