CORDIS Project
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This project examines how the stiffness of the extracellular matrix influences cell behavior in the vascular system. It focuses on the roles of specific proteins in endothelial and smooth muscle cells, aiming to understand their contributions to age-related cardiovascular disease.
The extracellular matrix (ECM) affects many aspects of cell growth and behavior.
Not only do cells respond to the composition of the ECM, but they also respond to its physical properties, adjusting to the stiffness of their physical environment by generating tension within the cytoskeleton.
In the vascular system, the large arteries from the central arterial system become stiffer with age.
It is now well established that arterial stiffening significantly contributes to cardiovascular disease (CV…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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