CORDIS Project
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This research investigates the mechanisms regulating stem cell proliferation, focusing on a novel pathway involving chromatin remodeling and the DNA damage response. The findings could lead to new strategies for brain repair and cancer treatment by manipulating stem cell behavior.
The self-renewing nature of stem cells is a consequence of their ability to proliferate indefinitely while maintaining pluripotency.
Mechanisms of pluripotency are well known but mechanisms controlling stem cell proliferation are unknown.
Proliferation of somatic cells takes place in G1 cell cycle phase.
We have identified that embryonic and peripheral neural stem cell proliferation is regulated by an entirely new mechanism involving chromatin remodeling and operating in the S/G2 phase of the ce…
KAROLINSKA INSTITUTET
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