CORDIS Project
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This project investigates the role of redox regulation in breast cancer stem cells, aiming to exploit their plasticity and oxidative metabolism as a therapeutic target. By analyzing patient-derived organoids, the project seeks to enhance the effectiveness of traditional chemotherapy and reduce cancer recurrence and spr…
ABSTRACT Breast cancer (BC) is the most frequently diagnosed cancer and the first cause of cancer death in women worldwide.
In many tumors, including BC, there is a population of cancer stem cells (CSCs) characterized for unlimited self-renewal and being resistant to conventional cancer therapies eventually leading to tumor relapses and metastases.
Breast CSCs (BCSCs) show high cellular plasticity and are capable of shifting between a proliferative epithelial-like (E) state and a quiescent mesen…
UNIVERSITA DEGLI STUDI DI TORINO
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Germany, Saarbrucken
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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