CORDIS Project
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This project investigates the aging of epidermal stem cells, focusing on how circadian rhythms influence their function and communication with their environment. The goal is to uncover molecular mechanisms that lead to impaired stem cell activity and potential tumorigenesis as organisms age.
Most adult stem cells are compartmentalized in functionally deterministic niches where they self-renew and maintain homeostasis.
From there, stem cells are instructed by combinations of signals and spatial tensile forces which they translate into a specific behavior.
However how stem cells spatiotemporally coordinate their stem cell potential with niche- and systemic cues is poorly understood.
These issues are essential since perturbations in stem cell function can cause tissue malfunction, such…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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