CORDIS Project
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This project develops a novel in vitro model of the bone marrow to study hematopoietic stem cell behavior. By creating a microfluidic system that mimics the stem cell niche, it aims to enhance understanding of stem cell dynamics and improve transplant outcomes for patients with blood cancers.
More than 30’000 patients with hematological malignancies greatly benefit from hematopoietic stem cell (HSC) transplants each year in Europe alone.
However, availability of transplant material for afflicted patients, prognosis, and relapse-free survival are all hindered by the limited quantity of HSCs available for therapy.
Despite several decades of research, HSC cannot be cultured in vitro without rapidly differentiating.
This is largely due to our poor understanding of the mechanisms that reg…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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