CORDIS Project
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This project explores the impact of cell size on stem cell function and aging. It aims to identify the mechanisms behind stem cell enlargement and its effects on rejuvenation and cancer development, using mouse models to investigate these relationships.
The failure to regenerate tissue underlies a challenging health issue in elderly. A main contributor to this decline is the loss of stem cell function during aging.
Despite the essential role of stem cells, it is unclear how they fail to maintain their functions during aging and disease. I discovered a new aspect of stem cell aging in vivo: cellular enlargement.
With age, stem cells increase in size leading to their functional decline.
However, it is unclear how size impacts stem cell fitness. M…
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