CORDIS Project
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This project investigates the development of the mammary gland by examining how stem cells differentiate and contribute to tissue formation. It aims to map the behavior of these stem cells during embryonic development and understand the molecular mechanisms that guide their fate and the overall growth of the gland.
Tissue development requires the orchestration of stem cell differentiation and morphogenesis, a process that is conspicuously observed in mammary gland (MG) branching.
The MG develops from an embryonic bud of mammary stem cells (MaSCs).
Although these stem cells are initially bipotent, giving rise to the outer (basal) and inner (luminal) layers of the adult gland, they become lineage restricted very early in embryogenesis, at around the time of the onset of branching morphogenesis.
The timing of…
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