CORDIS Project
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This project investigates the mechanisms of cell migration and invasion in the intestinal epithelium, particularly in the context of cancer. It aims to understand how cancer cells interact with surrounding cells and the extracellular matrix during tumor progression.
The entire intestinal epithelium is renewed every week due to cell division in the crypts coupled with cell migration towards the villi and loss of cells by apoptosis at the tip of villi.
Uncoupling cell proliferation from apoptosis and possibly from cell migration can lead to pathologies such as cancer.
In carcinoma in situ, the basement membrane (BM) represents a physical barrier that prevents spreading of the primary tumor to adjacent tissues.
It is believed that cancer cells perforate BM, bu…
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