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The STAR project focuses on understanding how lipid-targeting antibiotics interact with bacterial membranes to combat drug-resistant infections. By utilizing advanced spectroscopy techniques, it aims to improve the development of new antibiotics with better efficacy and safety.
Antimicrobial resistance (AMR) is escalating due to multidrug-resistant (MDR) bacteria and a dwindling antibiotic pipeline and is projected to cause up to 10 million deaths annually by 2050.
Lipid-targeting (LT) antibiotics such as daptomycin and polymyxins combat MDR infections by disrupting bacterial membranes, yet their mechanisms remain unclear due to major technical challenges for structural biology.
This knowledge gap hinders the development of next-generation LT-antibiotics with improved…
UNIVERSITEIT UTRECHT
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