CORDIS Project
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This project aims to create a synthetic model of G-protein coupled receptors using squaramides to transmit information across cell membranes. By designing a relay system that responds to ligand binding, it seeks to mimic natural signaling pathways, contributing to advancements in synthetic biology and membrane technolo…
G-protein coupled receptors (GPCRs) are transmembrane proteins that are used by cells to transmit information through their membranes; binding of a ligand to their extracellular region provokes a conformational change, initiating a biological process in the cytosol.
Copying this type of signaling pathway, which is fundamental to cells and thus a key target in medicinal chemistry, is a fascinating challenge that could allow researchers to bypass endogenous signaling pathways in cells and lead to…
THE UNIVERSITY OF MANCHESTER
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