CORDIS Project
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This project focuses on developing a novel diagnostic tool for tauopathies, including Alzheimer's Disease, by utilizing nanopore technology to detect abnormal Tau proteins in biological fluids. The goal is to improve early diagnosis and monitoring of these neurodegenerative diseases.
Abnormal post-translational modifications (PTMs) can lead to the aggregation of Tau proteins, which characterize a wide range of neurodegenerative diseases known as tauopathies.
Some abnormal Tau proteins will be released into biological fluids, providing a chance for minimally- or non-invasive diagnosis.
For Alzheimer's Disease (AD), site-specific phosphorylations and truncations are representative PTMs that have been proved as biomarkers for its early diagnosis and progression monitoring.
To d…
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