CORDIS Project
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This project investigates the spliceosome, a complex responsible for RNA splicing. By studying the interactions between RNA and proteins involved in splicing, the goal is to reconstitute and visualize the structure of the spliceosome, providing insights into its dynamics and function.
The spliceosome is a ribonucleoprotein machine that excises introns from pre-messenger RNAs.
During my phD, I identified RNA ligands for the magnesium ions that catalyze these splicing reactions and showed that the spliceosomal U6 and U2 small nuclear RNAs form a structure resembling group II self-splicing intron RNAs.
Although the spliceosome's catalytic core is RNA-based, numerous spliceosomal proteins promote the proper catalytic fold of this RNA core, juxtapose the reactive pre-mRNA elements…
UNITED KINGDOM RESEARCH AND INNOVATION
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