CORDIS Project
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This project investigates how alternative splicing in neurons contributes to the diversity of molecular tags that guide synaptic connections. By utilizing advanced sequencing techniques, it aims to enhance understanding of synaptic specificity and its implications for disorders like autism.
Neuronal networks represent an impressive example of highly organized complex systems.
Sperry postulated that selective neuronal connectivity is achieved by chemoaffinity labels.
Several such labels for axon guidance and topographic mapping have been defined.
However, until recently, molecules that direct the recognition of synaptic partners and functional specification of synapses have remained obscure.Chemoaffinity tags are envisioned to provide a recognition code that would encompass the reco…
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