CORDIS Project
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The SPiN project uses nucleomorphs to investigate nuclear architecture and gene expression through advanced cryogenic electron microscopy techniques. It aims to reveal insights into pre-mRNA splicing and the spatial organization of gene expression, with implications for evolutionary biology and biotechnology.
The ""Splicing Processes in Nucleomorphs"" (SPiN) project leverages the unique properties of nucleomorphs to explore in situ the nuclear architecture and gene expression at an unprecedented level.
Using cutting-edge cryogenic electron microscopy (cryo-EM) techniques such as tomography, subtomogram averaging and single particle analysis, I want to provide novel understanding of how pre-mRNA splicing happens in the context of genome reduction. I will overcome the limitations of current cryo-ET stu…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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