CORDIS Project
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The SPHERES project investigates the mechanisms behind adipocyte hypertrophy, focusing on lipid droplet dynamics and their role in metabolic diseases. By exploring the structural and functional changes in adipocytes, the project aims to uncover new therapeutic strategies for related health issues.
The goal of SPHERES is to understand the dynamics and consequences of adipocyte hypertrophy (enlargement) through investigation of its large lipid droplet (LD).
The adipocyte LD is a unique organelle specialized in storing energy in triglycerides (TGs).
Its surface is composed of a phospholipid monolayer and specific LD-associated proteins (such as perilipins, CIDEs and lipases), which jointly regulate LD stability and TG turnover.
Adipocyte hypertrophy due to an increase in LD size may, irrespe…
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Sweden, Stockholm
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
France, Nice
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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