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The SPECADE project investigates how specific signaling pathways and the extracellular matrix influence the differentiation of embryonic stem cells into anterior definitive endoderm, which can develop into vital organs like the pancreas and liver. This research aims to enhance our understanding of cell fate decisions a…
Deciphering the specific role of signalling and the niche in which cells develop and differentiate is one of the central problems of developmental biology.
Approaching this problem has been difficult in vivo, as embryonic development involves complex signalling machinery directly instructing the cell fate, or influencing the environment which itself drives the cell specification.
Embryonic stem (ES) cell technology affords a new approach, allowing in vitro reconstitution of elements guiding cell…
KOBENHAVNS UNIVERSITET
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