CORDIS Project
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This project investigates how dendritic cells interact with naive CD8 T cells to initiate adaptive immunity. By using advanced imaging techniques, it aims to uncover the cellular mechanisms that regulate T cell differentiation during a crucial phase of immune response, which could lead to new therapies for infections a…
The initiation of adaptive cellular immunity requires antigen-specific interactions between Dendritic cells (DC) and naive CD8 T cells in secondary lymphoid organs.
We aim to understand how the dynamic migratory behavior of myeloid and lymphoid cells is coordinated to ensure that “the right cells” communicate at “the right time” in “the right place” to enable robust immune responses.
Using intravital microscopy, we have recently identified a critical phase (“Step 2”) of T cell priming that follo…
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
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