CORDIS Project
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This project investigates the metabolic environments created by tumors that suppress immune cell function. By quantifying immune cell metabolism in human cancers, it aims to identify metabolic states that predict responses to cancer immunotherapy, potentially leading to improved treatment strategies.
The success of cancer immunotherapy, especially immune checkpoint inhibition (ICI), demonstrates the ability of the immune system to fight tumors.
However, only a fraction of patients benefit from currently available therapies, and we need to find novel approaches to improve clinical responses.
Cellular metabolism has emerged as a key determinant of multiple aspects of immune cell function, especially T cell exhaustion and anti-inflammatory macrophage polarization.
However, we currently do not h…
DEUTSCHES KREBSFORSCHUNGSZENTRUM HEIDELBERG
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