CORDIS Project
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The project explores the role of specific genes associated with hereditary spastic paraplegias in regulating receptor trafficking and signaling in neurons. Using the fruit fly model, it aims to understand how mutations in these genes contribute to motor neuron degeneration.
The hereditary spastic paraplegias (HSPs) are a group of neurodegenerative conditions characterised by the degeneration of longer spinal cord motor tract axons.
The normal function of the 13 cloned spastic paraplegia genes (SPGs) is largely unknown, but most encode intracellular membrane-associated proteins.
Recently, the host laboratory has established that one of these genes, SPG6, encodes an endosomal regulator of BMP receptor trafficking, and regulates synaptic growth and axonal microtubules…
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