CORDIS Project
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The SPArKLE project investigates the role of the metabolite succinate and the enzyme pyruvate kinase in immune cell function, particularly in CD4+ T lymphocytes. This research aims to identify new therapeutic targets for autoimmune and allergic diseases through a multidisciplinary approach.
Despite major advances in the development of novel immunomodulatory drugs, the incidence of many immune disorders such as allergic and autoimmune diseases is increasing worldwide, particularly in Western countries.
Innovative therapeutic targets must be identified to limit the social and economical impact of such pathologies, and a better understanding of the pathways involved in immune cell activation and functionality is needed.
The SPArKLE action will provide an outstanding training programme…
THE PROVOST, FELLOWS, FOUNDATION SCHOLARS & THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY & UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN
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