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The SOX10mutants project explores neural crest development using zebrafish models to study mutations in the SOX10 gene linked to developmental disorders. This research aims to clarify the relationship between genetic mutations and associated symptoms in conditions like Waardenburg syndrome.
Neural crest formation is a critical event in development, giving rise multiple cell types including melanocytes, neurons and glia.
This complex process is governed by a network of transcription factors, such as PAX3 and SOX10 and mutations in these genes have been associated with developmental syndromes.
Waardenburg syndrome (WS) and Hirshsprung disease are examples of these neurocristopathies and patients suffer symptoms ranging from sensorineural hearing loss and pigmentation defects to intes…
UNIVERSITY OF BATH
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