CORDIS Project
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This project investigates the role of Sox2, a transcription factor, in regulating stem cell fate and its involvement in tumor formation. Using mouse skin as a model, it aims to identify Sox2 target genes and their functions in cancer progression through advanced profiling techniques and gene screening.
The Sox family of transcription factors are versatile regulators of stem and progenitor cell fate.
Sox2 is a well-characterized member of this family and plays essential roles during animal development and in adult stem cells.
Accumulating evidence suggests that dysregulation of Sox2 expression is involved in key steps during tumorigenesis.
However, the underlying molecular mechanisms of Sox2 in tumor formation and the Sox2 target genes mediating these phenotypes remain elusive.Here, using mouse…
University of Zurich
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