CORDIS Project
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This project focuses on Sortilin, a receptor that plays a key role in protein trafficking within cells. It aims to identify new cytosolic adaptors that regulate Sortilin's function and trafficking, which is crucial for understanding cellular processes and the development of diseases.
Protein trafficking is crucial to maintain organelle function and cellular homeostasis, and is regulated by sorting receptors.
Sortilin is a membrane receptor that sorts proteins to the predisposed cellular compartments through both secretory and endocytic routes.
To accomplish this function Sortilin is endowed with an ectodomain that binds a great variety of cargo proteins, and a cytosolic domain that recruits adaptor proteins to direct the receptor trafficking activities.
In the last 15 years…
AARHUS UNIVERSITET
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