CORDIS Project
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This project investigates the role of the sorting receptor SorCS1 in regulating the balance between excitatory and inhibitory signals in the brain. It aims to understand how SorCS1 affects synaptic function and its implications for neuropsychiatric disorders.
Controlling the precise balance between excitation and inhibition (E/I balance) is critical for information processing in the brain. A perturbed E/I balance has been implicated in the etiology of a wide range of neuropsychiatric disorders.
The factors that dictate the balance between excitatory and inhibitory synaptic transmission are still poorly defined, but trans-synaptic interactions between adhesion molecules such as neurexins and neuroligins are thought to be important.
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