CORDIS Project
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This project investigates the accumulation of genetic mutations in kidney cells, particularly in the proximal tubule, to understand how these mutations contribute to cancer development. It aims to explore the relationship between cellular metabolism and genomic damage, potentially leading to strategies for cancer preve…
An important factor favoring cancer initiation is the lifelong accumulation of somatic mutations in the genome.
In agreement, somatic mutations in a specific set of driver genes has been shown to drive the transition from a healthy cell to a tumorigenic clone in the kidney.
The vast majority of kidney tumors originate from a specific segment of the kidney nephron, named proximal tubule (PT).
However, the rate of somatic mutation accumulation before tumorigenic transformation in the kidney PT and…
OSPEDALE SAN RAFFAELE SRL
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