CORDIS Project
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This project explores the biological function of sleep by examining how the brain reacts to sleep deprivation. It aims to uncover the molecular mechanisms that regulate sleep-inducing neurons, potentially linking sleep, energy metabolism, and oxidative stress.
Sleep is vital and universal, but its biological function remains unknown.
This project will seek to understand why we need to sleep by studying how the brain responds to sleep loss.
My previous work in Drosophila showed that rising sleep pressure activates two dozen sleep-inducing neurons in the dorsal fan-shaped body (dFB) of the central complex.
Sleep need is encoded in the electrical excitability of these neurons, which fluctuates because two potassium conductances, voltage-gated Shaker and…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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